Impact on the Kidney of Pancreas Damage due to Streptozotocin-Induced Hyperglycemia

Highlights: This study observed the histology of pancreatic β-cell damage without any intervention to kidneys animal models. The histological analysis shows that STZ-induced models can be used for assessing kidney abnormalities due hyperglycemia. A scoring system was developed evaluate changes in cells. Abstract are one organs affected by microvascular complications diabetes mellitus. Hyperglycemia plays an important role glomerular, mesangial cell, and tubular kidneys. Metabolic dysregulation, including hyperglycemia, initiates cellular Streptozotocin (STZ) is a chemical compound known cells cause aimed examine effects hyperglycemia on morphology Kidney tissues were histologically using light microscope. Samples taken from experimental animals administered with STZ induce Observation performed afterwards investigate total 12 samples divided into two groups: control group group. prepared before staining hematoxylin-eosin Masson's trichrome. endothelium, podocytes, cells, basement membrane glomerulus examined. tubules also examined, presence or absence connective tissue formation both groups statistically tested. results suggested significant difference (p<0.05) insignificant increase other components (p>0.05) Significant morphological hyperglycemic renal administration STZ. In conclusion, caused but overall had no impact kidney.